Allergic Reaction To Fish

Allergic reaction to fish has played a primary role in the study of adverse reactions to food as a fish study has shown for the first time the presence of a serum related to this allergy and that this factor (then identified in IgE) could be passively transferred to a normal subject. It was the so-called Prausnitz and Künstner test (P-K test). In 1921, two German physicians Otto Carl W. Prausnitz and Heinz Künstner performed the following experiment: 24 hours after injecting intradermally a small amount of Künstner’s whey, which was allergic to fish, in the skin of Prausnitz, in that same area skin was injected with an allergenic fish extract with within a few minutes of erythemato-pomphoid reaction.

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